Neymar left the pitch in tears as he was stretchered off against Lyon on Sunday night.
It came in the dying moments of Paris Saint-Germain’s 1-0 loss to their Ligue 1 rivals that has seen Lille remain at the top of the table.
Tino Kadewere grabbed the only goal of the night in the first-half.
But there were further problems for Thomas Tuchel after a late challenge from Thiago Mendes on Neymar.
It left the Brazilian in agony and he had to be stretchered off after what looks like another serious ankle injury.
The challenge also saw Mendes sent off but it had no bearing on the result as Lyon hung on.
Early suspicions suggest it could be a very serious injury to Neymar, with videos showing his ankle possibly broken.
His ankle appears to be twisted the wrong way round as it became caught in Mendes’ leg.
Neymar has had rancid luck with injuries while at PSG, but this one could be the worst of the lot.
During his time in Paris, the Brazil international has fractured his metatarsal on two separate occasions.
He also missed the Copa America in 2019 after rupturing ankle ligaments.
The 28-year-old signed for PSG in 2017 but his injury history has meant he has played just 58 times for the French giants.
As for the performance, the Ligue 1 champions put on a lacklustre display against Lyon which has seen them drop into third.
Kadewere’s strike was enough to down Tuchel’s men, with the German manager still under pressure.
Prior to the win over Manchester United in the Champions League, the former Borussia Dortmund boss was on the edge of being sacked with PSG on the cusp of failing to qualify.
But he bought himself some time after topping the group with two wins out of two, though their domestic form leaves much to be desired.
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Lille went top of the table after beating Girondins de Bordeaux 2-1 earlier in the day.
Christophe Galtier’s men have 29 points from 14 games, leading second-placed Lyon on goal difference with PSG on 28 points after their fourth defeat of the season.
Olympique de Marseille are fourth on 27 points with two games in hand, in a tight top five separated by three points.